ea0009p88 | Endocrine tumours and neoplasia | BES2005
McVittie C
, Ogunkolade W
, Khalaf S
, Macaulay V
, Bustin S
, Carpenter R
, Jenkins P
Introduction: The GH/IGF-I axis has been implicated in the pathogenesis of breast cancer and development of tamoxifen resistance. We have previously used siRNA to successfully silence the IGF-I receptor (IGF-IR) in MCF-7 breast cancer cells. To further characterize the growth changes that occur when elements of the GH/IGF-I axis are disrupted we investigated the use of siRNA to cause long term silencing of IGF-IR.Methods: MCF-7 cells were cultured in phe...